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NF-κB/MAPK-IN-1

CAS No. : 2413940-56-2

Biological Activity：NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC₅₀ of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research.

Research Area：Inflammation/Immunology

Targets：NF-κB|p38 MAPK|NO Synthase|COX

Related Small Molecules:Carboxy-PTIO potassium;Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;Valeriandoid F;Icariside F2;IKKγ NBD Inhibitory Peptide TFA;Ciwujianoside C3;Mangiferin;Antioxidant agent-5;ALPK1-IN-1;NOS-IN-3;Regaloside A;SB-747651A dihydrochloride;IMD-ferulic;SN52;Dehydrocorydaline;Ampyrone;COX-2-IN-24;5-Aminosalicylic Acid-D3 hydrochloride;SKF-86002 dihydrochloride;Ginsenoside Rg1;Echinulin;Aminopicoline;Licochalcone D;Zaltoprofen-d7;QNZ;trans-Isoferulic acid;BIZ 114

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