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MPP+-d3(iodide)

CAS No. : 207556-07-8

Biological Activity：MPP+-d3(iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson’s disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)^[2].

Research Area：Neurological Disease

Targets：Mitochondrial Metabolism

Related Small Molecules:MitoTam bromide, hydrobromide;MitoTEMPO hydrate;NL-1;Thiabendazole-d4;D-Histidine;Mito-apocynin (C2);Fumarate hydratase-IN-2 sodium salt;Schaftoside;Daidzin;Azemiglitazone;Tempo;Idebenone;Menadiol;CTPI-2;Senecionine acetate;Antimalarial agent 14;Mito-apocynin (C11);OXPHOS-IN-1;Mitochondrial respiration-IN-1 hydrobromide;Tubulin/HDAC-IN-1;Clidanac;IMT1;Nonactin;RYL-552;DX2-201;MSDC 0160

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