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Laduviglusib monohydrochloride
CAS No. : 1797989-42-4
Biological Activity：Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy[2][3].
Research Area：Cancer
Targets：Wnt|Autophagy|GSK-3|β-catenin
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Antidepressant Compound Library;Human Metabolite Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:TCS2002;AR-A014418;Wnt/β-catenin agonist 1;GSK 3 Inhibitor IX;ARUK3001185;Gallocyanine chloride;Fz7-21;NRX-252114;MeBIO;Foxy-5 TFA;Cromolyn-d5 sodium;GS87;Wnt/β-catenin agonist 4;JW74;IQ 1;Heparan Sulfate;ZDWX-25;ARN25068;CDK8-IN-11 hydrochloride;ETC-159;PfGSK3/PfPK6-IN-2;(E)-Ferulic acid-d3;RGB-286638;Laduviglusib (GMP);GSK3 Substrate, α, β subunit;NRX-252262;DIF-3;Bikinin;Toxoflavin
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