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Gliotoxin
CAS No. : 67-99-2
Biological Activity：Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells[3].
Research Area：Infection|Inflammation/Immunology
Targets：Fungal|NF-κB|PKA|Bacterial|Antibiotic|Apoptosis
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