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XST-14
CAS No. : 2607143-50-8
Biological Activity：XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.
Research Area：Cancer
Targets：p38 MAPK|CaMK|ULK|Anaplastic lymphoma kinase (ALK)|Apoptosis|TGF-β Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Neuronal Signaling Compound Library;Protein Tyrosine Kinase Compound Library;TGF-beta/Smad Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;ALK-IN-9;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;ML347;Bafetinib
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