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WRG-28
CAS No. : 1913291-02-7
Biological Activity:WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice[2].
Research Area:Cancer|Inflammation/Immunology
Targets:Discoidin Domain Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Breast Cancer Compound Library;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:JNK3 inhibitor-2;DDR2-IN-1;DDR1-IN-1 dihydrochloride;CHMFL-ABL/KIT-155;DDR1-IN-6;Merestinib;DDR Inhibitor;DDR1-IN-4;BAY-826;ML786 dihydrochloride;VU6015929;DDR1-IN-5;FGFR1/DDR2 inhibitor 1;DDR-TRK-1;Sitravatinib malate;7rh
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