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MK2-IN-3 hydrate

CAS No. : 1186648-22-5

Biological Activity：MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC₅₀ of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC₅₀=0.21 μM), MK-5 (IC₅₀=0.081 μM), ERK2 (IC₅₀=3.44 μM), MNK1(IC₅₀=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2.

Research Area：Inflammation/Immunology

Targets：MAPKAPK2 (MK2)

Related Small Molecules:CMPD1;MK2-IN-1 hydrochloride;RMM-46;Zunsemetinib;DB1113;Tpl2 Kinase Inhibitor 1;MMI-0100;MK2-IN-4;CC-99677;Norartocarpetin;PF-3644022

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