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MK2-IN-3
CAS No. : 724711-21-1
Biological Activity：MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo.
Research Area：Inflammation/Immunology
Targets：MAPKAPK2 (MK2)
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Oxygen Sensing Compound Library;Targeted Diversity Library;Cancer Stem Cells Compound Library;
Related Small Molecules:CMPD1;MK2-IN-1 hydrochloride;RMM-46;Zunsemetinib;DB1113;Tpl2 Kinase Inhibitor 1;MMI-0100;MK2-IN-4;CC-99677;MK2-IN-3 hydrate;Norartocarpetin;PF-3644022
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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