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IACS-13909
CAS No. : 2160546-07-4
Biological Activity：IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. IACS-13909 is more selective for SHP2 than other phosphatases (including SHP1). IACS-13909 has antitumor activities and suppresses MAPK pathway signaling in receptor tyrosine kinases (RTK)-dependent cancers.
Research Area：Cancer
Targets：SHP2|Phosphatase
Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Phosphatase Inhibitor Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:GNF362;ZLDI-8;Uralenol;SHP504;Trimyristin;SHP099 hydrochloride;MY10;PTP1B-IN-3 diammonium;Calyculin A;LMPTP inhibitor 1 dihydrochloride;[pTyr5] EGFR (988-993) (TFA);RMC-3943;AS1949490;PGAM1-IN-1;TD52 dihydrochloride;bpV(phen);EDP-305;CCT007093;(E/Z)-Icerguastat;ARL67156 trisodium;Cytostatin;SHP394;PTP1B-IN-4;EWP 815;PTP1B-IN-2;CD31 TFA;SHP389;NSC 663284
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