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Chelerythrine
CAS No. : 34316-15-9
Biological Activity：Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].
Research Area：Cancer|Metabolic Disease|Inflammation/Immunology
Targets：Autophagy|PKC|Bcl-2 Family|Apoptosis
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;[Ala107]MBP(104-118) TFA;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;Myelin Basic Protein;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;BI-3812;Xevinapant;Mangiferin;Cambinol;PKC-iota inhibitor 1;Antioxidant agent-5
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