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BMS-986251
CAS No. : 2460133-35-9
Biological Activity：BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis).
Research Area：Inflammation/Immunology
Targets：Interleukin Related|ROR
Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;AX-024;RORγt inverse agonist 30;GNE-0946;Ginsenoside F3;Perakizumab;RORγt inverse agonist 13;PNRI-299;CTX-471;Ac-YVAD-CHO;Deucravacitinib;Vimirogant hydrochloride;SR2211;Bevurogant;Mulberroside A;NFAT Transcription Factor Regulator-1;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;ROR agonist-1;RORγt Inverse agonist 8;5(S)15(S)-DiHETE;IL-17A inhibitor 2;Anti-Mouse IL-1b Antibody;Raleukin;Ossirene;VGX-1027
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