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AS601245
CAS No. : 345987-15-7
Biological Activity：AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[2].
Research Area：Cancer|Inflammation/Immunology|Neurological Disease
Targets：JNK
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Orally Active Compound Library;Neuroprotective Compound Library;Anti-Parkinson’s Disease Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Antidepressant Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;JNK3 inhibitor-2;JIP-1(153-163) TFA;TOPK-p38/JNK-IN-1;JNK-IN-8;JNK3 inhibitor-4;Sesamolin;Astragaloside IV;Tomatidine;(-)-Zuonin A;JNK3 inhibitor-1;Polyphyllin I;IQ-3;MAPK-IN-1;CT1-3;SR-3306;JNK3 inhibitor-3;BI-78D3;DB07268;JNK3 inhibitor-5;Guggulsterone;Urolithin B;Loureirin B;JNK-IN-7;MPT0B392;TCS JNK 5a;Anisomycin;IMM-H007
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