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AChE-IN-14
CAS No. : 2390042-05-2
Biological Activity：AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease.
Research Area：Neurological Disease
Targets：Histamine Receptor|Cholinesterase (ChE)
Related Small Molecules:Piperilate;Tripelennamine;BuChE-IN-5;Brompheniramine-d6 maleate;Samelisant;Chlorphenoxamine;AChE/BChE-IN-10;H3 receptor-MO-1;Diphenhydramine;Timosaponin AIII;ABT-239;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Ketotifen fumarate;Sinapine thiocyanate;Ranitidine;sEH/AChE-IN-1;AChE-IN-11;Cetirizine
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