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K41498
CAS No. : 434938-41-7
Biological Activity：K41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α– and hCRF2β-expressing cells. K41498 can be used for hypotension study.
Research Area：Cardiovascular Disease
Targets：CRFR
Related Small Molecules:Stresscopin-related peptide (human);Sauvagine;CRF(6-33)(human) TFA;NBI-27914;Urocortin III, mouse;Emicerfont;R121919;CP 316311;Pexacerfont;Urotensin I TFA;Urocortin, rat TFA;Urocortin II, human TFA;α-Helical CRF(9-41);CP 376395;Urocortin, human;CRF, bovine TFA;Tildacerfont;Cortagine;Antisauvagine-30 TFA
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